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A Cincinnati Methotrexate regimen comprised of an intraoperative intraocular infusion and four intravitreal injections at postoperative weeks 1, 3, 6 and 10 was associated with higher single surgery success, lower postoperative proliferative vitreoretinopathy, and superior visual acuity in complex retinal detachment repair with proliferative vitreoretinopathy grade C compared to a contemporaneous consecutive comparator cohort.
This cohort study demonstrates that eyes with pachychoroid subtype are largely stable over a 2-year period, with a low incidence of diagnostic progression and preservation of visual and anatomical outcomes. Most progression events occurred within the first year of follow-up, while late diagnostic change was uncommon. Neovascularization was rare and occurred exclusively in eyes with shallow, irregular RPE elevation at baseline, highlighting the importance of this imaging feature in risk stratification.
For infants younger than 1 year with Congenital nasolacrimal duct obstruction, lacrimal sac massage for 3 months was noninferior to lacrimal duct probing in efficacy, with no serious complications in either group. These findings support lacrimal sac massage as an alternative to surgical probing for Congenital nasolacrimal duct obstruction in infants younger than 1 year similar to those enrolled in this trial.
