This article presents a clinical case series that aims to describe novel observations of polypoidal choroidal vasculopathy (PCV) using three-dimensional (3D) reconstruction of swept source OCT angiography (SS-OCTA) images.

The study compares these observations with similar images of type I neovascular age-related macular degeneration (nAMD). The study included patients with PCV in either eye, and the images were obtained and reconstructed in 3D using a pre-specified SS-OCTA imaging protocol.

The researchers evaluated three specific features:

the pattern of flow signal within the polypoidal lesions (PLs).

the configuration of the branching neovascular network (BNN), and.

the spatial arrangement of the PLs in relation to the BNN.

The results showed that all PLs exhibited internal vascular architecture in the form of coil-like loops and none exhibited homogenous flow. Small focal nodules were present within this internal vascular architecture in 70% of cases.

The BNN exhibited a hypermature/mature configuration and was associated with thicker choroid compared to typical nAMD type I neovascularization.

The study concludes that proliferating vasculature is present in both the PL and the BNN, and the configuration suggests that the BNN represents a more chronic and inactive lesion than the PL. The findings provide insights into the nature and structure of PCV and its component parts.

The article is available at the following address: [Polypoidal choroidal vasculopathy: evaluation based on 3-dimension reconstruction of OCT angiography – Ophthalmology Retina].