Keloids and Scars: A Potential Predictor of Post-op Complications in Retinal Detachment Repair

For ophthalmologists treating rhegmatogenous retinal detachment (RRD), a recent study offers intriguing insights into potential risk factors for post-operative complications. Researchers investigated a possible link between a patient’s history of cutaneous keloids, hypertrophic scarring, and fibrosis (KHF) and the development of proliferative vitreoretinopathy (PVR) after RRD repair.

Study Design and Findings:

  • This was a retrospective, cohort study analyzing data from over 2,000 patients who underwent RRD repair.
  • Patients were divided into two groups based on their dermatological history: KHF and non-KHF.
  • The study found a significantly higher rate of PVR diagnosis within 180 days of surgery in the KHF group compared to the non-KHF group (10.1% vs. 3.4%).
  • Additionally, patients with KHF were more likely to require complex re-surgery to address ongoing complications.
  • Similar trends were observed when analyzing all retinal detachment repair types, not just pars plana vitrectomy.

Key Takeaways:

  • This study suggests a potential association between KHF and increased risk of PVR after RRD repair.
  • While further research is needed to confirm causality, these findings offer valuable insights for preoperative considerations.
  • Identifying patients with KHF beforehand may necessitate closer monitoring and potentially influence surgical approach or patient counseling.

Future Directions:

  • Larger, prospective studies are needed to validate these findings and explore underlying mechanisms linking KHF and PVR.
  • Investigating potential treatment strategies to mitigate PVR risk in patients with KHF is crucial.
  • Further research into genetic or biological factors contributing to both conditions might shed light on potential shared pathways.


This study highlights the potential importance of considering a patient’s dermatological history in the context of RRD repair. Identifying KHF as a possible risk factor for PVR can inform preoperative discussions, potentially improving overall patient outcomes. It’s important to remember that this research is at an early stage, and further studies are needed to confirm and expand upon these findings.

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