Influence of Carotid Endarterectomy on Choroidal Perfusion: The INFLATE Study

The article “Influence of Carotid Endarterectomy on Choroidal Perfusion: The INFLATE Study” by Yi Zhang et al. published in Ophthalmology Retina, explores the impact of carotid artery endarterectomy (CEA) on choroidal blood flow.

The study was conducted using swept-source OCT angiography (SS-OCTA) imaging protocol on patients with clinically significant carotid artery stenosis (CAS) before and after CEA. The main outcome measures were changes in mean choroidal thickness (MCT) and choroidal vascular index (CVI).

The study included 60 patients with a mean age of 71.57 ± 7.37 years.

Baseline MCT was thinner on the surgical side compared to the nonsurgical side, while no significant differences were seen in CVI. However, within one week after CEA, there were significant increases in MCT on the surgical side.

Multivariable regression analysis showed that baseline MCT significantly decreased with age on both sides. The study concludes that there is a rapid and significant increase in MCT on the ipsilateral side of CEA, indicating improved choroidal perfusion after surgery

(Yi Zhang et al., Ophthalmol Retina, 2023).

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